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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
May -2009 / Volume - 1 /Issue - 3/Article No - 2 / Research Article
DEVELOPMENT AND IN-VITRO EVALUTION OF EFFERVASCENT FLOATING TABLETS USING GUAR-GUM AS NATURAL HYDROCOLLOID
Ramesh B. Parmar*,1 Ashok H. Baria, 1
Shital D. Faldu, 1
Darshan H Parekh, 2 Dr. H. M. Tank2
1Depart of Pharmaceutics, S. J. Thakkar Pharmacy College, Kalawad Road,
Rajkot-360 005, Gujarat, India.
2Depart of Pharmaceutics, S. S. Institute of Pharmaceutical Education and Research,
Hadala, Rajkot-360005, Gujarat, India.
DEVELOPMENT AND IN-VITRO EVALUTION OF EFFERVASCENT FLOATING TABLETS USING GUAR-GUM AS NATURAL HYDROCOLLOID
Ramesh B. Parmar*,1 Ashok H. Baria, 1
Shital D. Faldu, 1
Darshan H Parekh, 2 Dr. H. M. Tank2
1Depart of Pharmaceutics, S. J. Thakkar Pharmacy College, Kalawad Road,
Rajkot-360 005, Gujarat, India.
2Depart of Pharmaceutics, S. S. Institute of Pharmaceutical Education and Research,
Hadala, Rajkot-360005, Gujarat, India.
Mr.R.B.Parmar
ABSTRACT
Amoxicillin is an extended spectrum aminopenicillin antimicrobial agent, most efficiently used in eradication of Helicobacter pylori. The present investigation is concerned with the development of the Gastro retentive floating tablets, containing amoxicillin, which after oral administration were designed to prolong the gastric residence time and thus to obtain better eradication rate and also to minimize the incident of bacterial resistance as well as side effects. Various formulations were developed by using Guar-gum as natural hydrocolloid; HPMC as a release rate controlling and gel forming polymer; Sodium bi-carbonate as gas generating agent. The air-pockets formed by effervescent of Sodium bi-carbonate within the floating system and natural hydrocolloid provided low density which lead to excellent in-vitro floating behavior of the tablets. All the formulations had floating lag time below 4 minutes and constantly floated on dissolution medium for more than 12 h. From among all the developed formulations, as F3 prolonged the drug release for longer period of time, they were nominated as best formulations. The best formulations followed power law kinetics while the drug release mechanism was found to be anomalous type, diffusion through the honeycomb network and polymer relaxation. Thus, best formulations satisfied physico-chemical parameters, floating time and in vitro drug release profile requirements for a floating drug delivery system.
Key Words: - Extended drug release; Floating drug delivery system; Sodium bi-carbonate;Guar-gum.
Amoxicillin is an extended spectrum aminopenicillin antimicrobial agent, most efficiently used in eradication of Helicobacter pylori. The present investigation is concerned with the development of the Gastro retentive floating tablets, containing amoxicillin, which after oral administration were designed to prolong the gastric residence time and thus to obtain better eradication rate and also to minimize the incident of bacterial resistance as well as side effects. Various formulations were developed by using Guar-gum as natural hydrocolloid; HPMC as a release rate controlling and gel forming polymer; Sodium bi-carbonate as gas generating agent. The air-pockets formed by effervescent of Sodium bi-carbonate within the floating system and natural hydrocolloid provided low density which lead to excellent in-vitro floating behavior of the tablets. All the formulations had floating lag time below 4 minutes and constantly floated on dissolution medium for more than 12 h. From among all the developed formulations, as F3 prolonged the drug release for longer period of time, they were nominated as best formulations. The best formulations followed power law kinetics while the drug release mechanism was found to be anomalous type, diffusion through the honeycomb network and polymer relaxation. Thus, best formulations satisfied physico-chemical parameters, floating time and in vitro drug release profile requirements for a floating drug delivery system.
Key Words: - Extended drug release; Floating drug delivery system; Sodium bi-carbonate;Guar-gum.