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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
February- 2010 / Volume - 1/ Issue - 12
( Total Articles =10 )
( Total Articles =10 )
ABSTRACT
Floating tablet of Furosemide (FUR) was prepared by direct compression technique. Furosemide was chosen as model drug because it is slightly soluble in water and poorly absorb from lower intestine. PEG-6000 is used as carrier agent for increasing solubility of Furosemide in water. Hydroxypropylmethylcellulose, sodium bicarbonate and carbopol were used as matrixing agent, gas generating agent and floating agent respectively. The tablets were evaluated for in-vitro buoyancy and dissolution studies Tablets were evaluated for physical characteristic viz. hardness, floating capacity, thickness, swelling index, and weight variation. Further, prepared floating tablets were evaluated for its in vitro release characteristic in comparison with conventional marketed tablet for 12 hrs. The data of in-vitro dissolution study of prepared floating tablet formulation showed zero order plots which was found to be fairly linear as indicated by its high regression value (R2=0.9772 to 0.9911). The optimized floating tablet batch (F3) shows drug release in a controlled manner with higher dissolution for 12 hr in comparison with conventional marketed tablet.
Keywords: Furosemide, Floating tablet, PEG 6000, HPMC
Floating tablet of Furosemide (FUR) was prepared by direct compression technique. Furosemide was chosen as model drug because it is slightly soluble in water and poorly absorb from lower intestine. PEG-6000 is used as carrier agent for increasing solubility of Furosemide in water. Hydroxypropylmethylcellulose, sodium bicarbonate and carbopol were used as matrixing agent, gas generating agent and floating agent respectively. The tablets were evaluated for in-vitro buoyancy and dissolution studies Tablets were evaluated for physical characteristic viz. hardness, floating capacity, thickness, swelling index, and weight variation. Further, prepared floating tablets were evaluated for its in vitro release characteristic in comparison with conventional marketed tablet for 12 hrs. The data of in-vitro dissolution study of prepared floating tablet formulation showed zero order plots which was found to be fairly linear as indicated by its high regression value (R2=0.9772 to 0.9911). The optimized floating tablet batch (F3) shows drug release in a controlled manner with higher dissolution for 12 hr in comparison with conventional marketed tablet.
Keywords: Furosemide, Floating tablet, PEG 6000, HPMC
February 2010 Issue
Article No 9
February - 2010 / Volume - 1 / Issue - 12 / Article No - 9 /Review Article
FORMULATION AND EVALUATION OF FLOATING TABLETS OF FUROSEMIDE
Vishal G. Karkhile*, Manish A. Sontakke,
Ritesh R. Karmarkar, S.D. Barhate and S.V. Tupkari.
.
*Department of Pharmaceutics,
Smt. Sharadchandrika. Suresh Patil
college of Pharmacy,
Chopda-425107, Maharashtra. India
E-Mail : man.ishk2001@gmail.com
February - 2010 / Volume - 1 / Issue - 12 / Article No - 9 /Review Article
FORMULATION AND EVALUATION OF FLOATING TABLETS OF FUROSEMIDE
Vishal G. Karkhile*, Manish A. Sontakke,
Ritesh R. Karmarkar, S.D. Barhate and S.V. Tupkari.
.
*Department of Pharmaceutics,
Smt. Sharadchandrika. Suresh Patil
college of Pharmacy,
Chopda-425107, Maharashtra. India
E-Mail : man.ishk2001@gmail.com
Vishal Karkhile
