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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
April -2009 / Volume - 1 / Issue -2/ Article No -1 / Research Article
“EVALUATION OF PHARMACOGNOSTICAL, PHYTOCHEMICAL AND PHARMACOLOGICAL ACTIVITY OF TEPHROSIA PURPUREA LINN”.
Miss.Surve Suvidha S.*., Miss. Patil Anuja
ABSTRACT
“EVALUATION OF PHARMACOGNOSTICAL, PHYTOCHEMICAL AND PHARMACOLOGICAL ACTIVITY OF TEPHROSIA PURPUREA LINN”.
Miss.Surve Suvidha S.*., Miss. Patil Anuja
ABSTRACT
The seed part of plant Tephrosia purpurea Linn. were selected for present study. Plant Tephrosia purpurea Linn. was collected during June 2007 from rural area of Shirur, The fresh seed were washed with tap water 3 to 4 time, cleaned and shade dried for several day, then crushed in coarse powered (200g) with the help of electric grinder and extracted with benzene, ethanol by using soxhlet apparatus successively with 600ml of each of solvent and aqueous extract by cold maceration.
The solvents are removed under reduced pressure. Extracts were concentrated to dryness at controlled temperature (40 - 50oC).
All the extracts were evaluated for anthelmintic activity. The benzene, ethanol, aqueous extracts of Tephrosia purpurea exhibited anthelmintic activity in dose-dependent manner giving shortest time of paralysis and death with 100mg/ml concentration for Pheretima posthuma. The benzene and ethanolic extracts were comparable in activity and took less time for paralysis and death compared with standard drug. While aqueous extract shown significant activity. Further, it will be interesting to isolate the possible phytoconstituents, which may be responsible for the anthelmintic activity.
The solvents are removed under reduced pressure. Extracts were concentrated to dryness at controlled temperature (40 - 50oC).
All the extracts were evaluated for anthelmintic activity. The benzene, ethanol, aqueous extracts of Tephrosia purpurea exhibited anthelmintic activity in dose-dependent manner giving shortest time of paralysis and death with 100mg/ml concentration for Pheretima posthuma. The benzene and ethanolic extracts were comparable in activity and took less time for paralysis and death compared with standard drug. While aqueous extract shown significant activity. Further, it will be interesting to isolate the possible phytoconstituents, which may be responsible for the anthelmintic activity.
Miss.Surve S.
Key Words: - Tephrosia purpurea, anthelmintic activity, Pheretima posthuma, Helminths, Parasitic worms.