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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
IJPRD
December - 2009 / Volume - 1/ Issue - 10
( Total Articles =10 )
( Total Articles =10 )
Article No 4
December -2009 / Volume - 1 / Issue - 10 / Article No - 4 / Research Article
DESIGN, OPTIMIZATION AND IN VITRO EVALUATION OF ORODISPERSIBLE TABLETS OF PHENIRAMINE MALEATE
Tejash Serasiya*1, Shailesh koradia1,
Subhash Vaghani1, N. P. JivaniI1.
1Smt, R.B. Patel Mahila Pharmacy College- ]
Atkot, Gujarat India.
E-mail: tjs_srsy@yahoo.com
December -2009 / Volume - 1 / Issue - 10 / Article No - 4 / Research Article
DESIGN, OPTIMIZATION AND IN VITRO EVALUATION OF ORODISPERSIBLE TABLETS OF PHENIRAMINE MALEATE
Tejash Serasiya*1, Shailesh koradia1,
Subhash Vaghani1, N. P. JivaniI1.
1Smt, R.B. Patel Mahila Pharmacy College- ]
Atkot, Gujarat India.
E-mail: tjs_srsy@yahoo.com
Mr. Tejash Serasiya
ABSTRACT
Orodispersible tablets of pheniramine maleate were prepared by direct compression method using various superdisintegrants like Crospovidone, croscarmellose sodium, sodium starch glycolate, low substituted hydroxypropyl cellulose, pregelatinized starch. The prepared tablets were evaluated for uniformity of weight, hardness, friability, wetting time, in-vitro disintegration time, in-vitro dispersion time and drug release study. All the formulation exhibited hardness between 3.3 - 3.6 kg/cm2. The tablets were disintegrating in-vitro within 20 to 51 sec. Dissolution studies revealed that formulations containing 10% Crospovidone and formulation containing 10% croscarmellose sodium showed 100% of drug release, at the end of six min.
The concentration of superdisintegrants had an effect on disintegration time and in-vitro drug dissolution whereas hardness and friability of resulting tablets were found to be independent of disintegrant concentration. The two formulations, one containing 10% of Crospovidone and second containing 10% croscarmellose sodium were found to give the best results. Thus, the tablets apart from fulfilling all official and other specifications and exhibited higher rate of release.
Key words: Orodispersible, pheniramine maleate, superdisintegrant, direct compression, in vitro.
Orodispersible tablets of pheniramine maleate were prepared by direct compression method using various superdisintegrants like Crospovidone, croscarmellose sodium, sodium starch glycolate, low substituted hydroxypropyl cellulose, pregelatinized starch. The prepared tablets were evaluated for uniformity of weight, hardness, friability, wetting time, in-vitro disintegration time, in-vitro dispersion time and drug release study. All the formulation exhibited hardness between 3.3 - 3.6 kg/cm2. The tablets were disintegrating in-vitro within 20 to 51 sec. Dissolution studies revealed that formulations containing 10% Crospovidone and formulation containing 10% croscarmellose sodium showed 100% of drug release, at the end of six min.
The concentration of superdisintegrants had an effect on disintegration time and in-vitro drug dissolution whereas hardness and friability of resulting tablets were found to be independent of disintegrant concentration. The two formulations, one containing 10% of Crospovidone and second containing 10% croscarmellose sodium were found to give the best results. Thus, the tablets apart from fulfilling all official and other specifications and exhibited higher rate of release.
Key words: Orodispersible, pheniramine maleate, superdisintegrant, direct compression, in vitro.
