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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
IJPRD
November - 2009 / Volume - 1/ Issue - 9
( Total Articles =10 )
( Total Articles =10 )
Article No 9
November -2009 / Volume - 1 / Issue - 9 / Article No - 9 /Research Article
SYNTHESIS AND EVALUATION OF SOME NEW QUINAZOLONE DERIVATIVES FOR THEIR ANTI MICROBIAL ACTIVITY
Jayshari S Pattan*3, Shashikant R .Pattan*1,
Nachiket S Dighe1,
C K Hariprasad2, S A Nirmal4, S N Hiremath5
November -2009 / Volume - 1 / Issue - 9 / Article No - 9 /Research Article
SYNTHESIS AND EVALUATION OF SOME NEW QUINAZOLONE DERIVATIVES FOR THEIR ANTI MICROBIAL ACTIVITY
Jayshari S Pattan*3, Shashikant R .Pattan*1,
Nachiket S Dighe1,
C K Hariprasad2, S A Nirmal4, S N Hiremath5
Jayshari S..Pattan
1 Department of Medicinal Chemistry,Pravara Rural College Of Pharmacy, Pravaranagar
2 Department of Medicinal Chemistry,K L E S College Of Pharmacy,Belgaum
3 Department of Microbiology, Pr. Dr Vikhe Patil College, Pravaranagar
4 Department of Pharmacognosy , Pravara Rural College Of Pharmacy, Pravaranagar
5 Department of Pharmaceutics, College of Pharmacy, Chincholi
2 Department of Medicinal Chemistry,K L E S College Of Pharmacy,Belgaum
3 Department of Microbiology, Pr. Dr Vikhe Patil College, Pravaranagar
4 Department of Pharmacognosy , Pravara Rural College Of Pharmacy, Pravaranagar
5 Department of Pharmaceutics, College of Pharmacy, Chincholi
ABSTRACT
The present work is a bonafide and novel for the synthesis of N1-3-(5-substituted-1, 3, 4-thiadiazol-2-yl)-(2-amino methyl) quinazolin4 (3H)-one derivatives.Around 30 new derivatives were synthesized, with the standard chemicals and well established procedures. The synthesized compounds were tested for their preliminary tests, physical constants, TLC, solubility, etc.The structures of the final compounds were confirmed by IR, 1H-NMR Spectra and CHN analysis.The proposed compounds were screened for their antimicrobial, antifungal, antitubercular and anti-inflammatory activities with the standard drugs in the well-equipped microbiology and pharmacology lab by using standard methods.
Key-words: Anti-microbial activity,Quinazolones,CHN analysis.
The present work is a bonafide and novel for the synthesis of N1-3-(5-substituted-1, 3, 4-thiadiazol-2-yl)-(2-amino methyl) quinazolin4 (3H)-one derivatives.Around 30 new derivatives were synthesized, with the standard chemicals and well established procedures. The synthesized compounds were tested for their preliminary tests, physical constants, TLC, solubility, etc.The structures of the final compounds were confirmed by IR, 1H-NMR Spectra and CHN analysis.The proposed compounds were screened for their antimicrobial, antifungal, antitubercular and anti-inflammatory activities with the standard drugs in the well-equipped microbiology and pharmacology lab by using standard methods.
Key-words: Anti-microbial activity,Quinazolones,CHN analysis.
