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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
IJPRD
November - 2009 / Volume - 1/ Issue - 9
( Total Articles =10 )
( Total Articles =10 )
Article No 5
November -2009 / Volume - 1 / Issue - 9 / Article No - 5 / Research Article
FORMULATION AND EVALUATION OF FLOATING MICROSPHERES OF KETOROLAC TROMETAMOL
Shashikant D. Barhate1*, Yogesh S. Rupnar, Rupesh M.
Sonvane, Kapil R. Pawar, Rahulkumar D. Rahane
November -2009 / Volume - 1 / Issue - 9 / Article No - 5 / Research Article
FORMULATION AND EVALUATION OF FLOATING MICROSPHERES OF KETOROLAC TROMETAMOL
Shashikant D. Barhate1*, Yogesh S. Rupnar, Rupesh M.
Sonvane, Kapil R. Pawar, Rahulkumar D. Rahane
Shashikant Barhate
Department of Pharmaceutics, Smt. S. S. Patil College of Pharmacy, Chopda - 425107. Maharashtra, India.
Email: ysrupnar@gmail.com
Email: ysrupnar@gmail.com
ABSTRACT
The objective of present study was to develop multiparticulate gastro retentive drug delivery system of ketorolac trometamol. The gastro retentive drug delivery system can be prepared to improve the absorption and bioavailability of ketorolac trometamol by retaining the system in to the stomach for prolonged period of time. The floating drug delivery system of ketorolac trometamol was prepared by emulsion solvent diffusion method by using ethyl cellulose, HPMC K4M, Eudragit R 100, Eudragit S 100 polymers in varying concentration. Formulations were evaluated for percent yield, particle size, entrapment efficiency, in vitro buoyancy and in vitro release studies. The optimized formulations shows good buoyancy and in-vitro controlled release of ketorolac trometamol.
Keywords: Floating microsphere, Ethyl cellulose, HPMC K4M, Eudragit R 100, Eudragit S100.
The objective of present study was to develop multiparticulate gastro retentive drug delivery system of ketorolac trometamol. The gastro retentive drug delivery system can be prepared to improve the absorption and bioavailability of ketorolac trometamol by retaining the system in to the stomach for prolonged period of time. The floating drug delivery system of ketorolac trometamol was prepared by emulsion solvent diffusion method by using ethyl cellulose, HPMC K4M, Eudragit R 100, Eudragit S 100 polymers in varying concentration. Formulations were evaluated for percent yield, particle size, entrapment efficiency, in vitro buoyancy and in vitro release studies. The optimized formulations shows good buoyancy and in-vitro controlled release of ketorolac trometamol.
Keywords: Floating microsphere, Ethyl cellulose, HPMC K4M, Eudragit R 100, Eudragit S100.
