ABSTRACT
Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
A simple, accurate and precise method for the simultaneous determination of amlodipine besylate and telmisartan in bulk drug and pharmaceutical dosage has been developed by RP-HPLC method. Separation was performed on a 5µm Prontosil C18 column (250 × 4.6mm ID) with methanol: potassium dihydrogen phosphate buffer at pH 4.5 (75:25v/v) , flow rate of 1.4 ml/ min and UV detection wavelength 240 nm. The calibration of the method was performad by concentration range of 2-20µg/ml for amlodipine and 16-160 µg/ml for telmisartan. The validation of proposed method was carried out for accuracy , precision, ruggedness,specificityfor both amlodipine and telmisartan the method can be used for routine quality analysis of tittled drug in tablet formulation.
Key words: Amlodipine, Telmisartan, Liquid chromatography, validation.
A simple, accurate and precise method for the simultaneous determination of amlodipine besylate and telmisartan in bulk drug and pharmaceutical dosage has been developed by RP-HPLC method. Separation was performed on a 5µm Prontosil C18 column (250 × 4.6mm ID) with methanol: potassium dihydrogen phosphate buffer at pH 4.5 (75:25v/v) , flow rate of 1.4 ml/ min and UV detection wavelength 240 nm. The calibration of the method was performad by concentration range of 2-20µg/ml for amlodipine and 16-160 µg/ml for telmisartan. The validation of proposed method was carried out for accuracy , precision, ruggedness,specificityfor both amlodipine and telmisartan the method can be used for routine quality analysis of tittled drug in tablet formulation.
Key words: Amlodipine, Telmisartan, Liquid chromatography, validation.
July 2011 Issue
July - 2011 / Volume - 3/Issue - 05
( Total Articles =25 )
( Total Articles =25 )
Article No 24
July - 2011 / Volume - 3 / Issue - 05/ Article No - 24 / Review Article
METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS DETERMINATION OF AMLODIPINE BESYLATE AND TELMISARTAN IN TABLET DOSAGE FORM BY RP- HPLC
S. D. Kayal1*, F.A.Khan1,
A.G.Tated1, R. L. Bakal1, A. V. Chandewar1
1Department of Pharmaceutical Chemistry,
P. Wadhwani College Of Pharmacy,
Yavatmal-445001, Maharashtra ,India.
July - 2011 / Volume - 3 / Issue - 05/ Article No - 24 / Review Article
METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS DETERMINATION OF AMLODIPINE BESYLATE AND TELMISARTAN IN TABLET DOSAGE FORM BY RP- HPLC
S. D. Kayal1*, F.A.Khan1,
A.G.Tated1, R. L. Bakal1, A. V. Chandewar1
1Department of Pharmaceutical Chemistry,
P. Wadhwani College Of Pharmacy,
Yavatmal-445001, Maharashtra ,India.
S.D. Kayal