ABSTRACT
Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
In the present study A series of chalconesemicarbazones was synthesized and evaluated for their antimicrobial activity by paper disk diffusion method against two strains each of gram positive and gram negative bacteria. Based on the results of an antibacterial study, most of the synthesized compounds were inactive against gram positive bacteria. Compound 28 was the most active compound against gram negative bacteria. It was found that chloro substitution in the aldehydic moiety and amino substitution in acetophenic moiety of chalcone exhibited better antibacterial activity against gram negative bacteria but lengthening of carbon chain does not favor antimicrobial activity.
Key words: Chalcones, Antimicrobial, Semicarbazones, Disk diffusion.
In the present study A series of chalconesemicarbazones was synthesized and evaluated for their antimicrobial activity by paper disk diffusion method against two strains each of gram positive and gram negative bacteria. Based on the results of an antibacterial study, most of the synthesized compounds were inactive against gram positive bacteria. Compound 28 was the most active compound against gram negative bacteria. It was found that chloro substitution in the aldehydic moiety and amino substitution in acetophenic moiety of chalcone exhibited better antibacterial activity against gram negative bacteria but lengthening of carbon chain does not favor antimicrobial activity.
Key words: Chalcones, Antimicrobial, Semicarbazones, Disk diffusion.
July 2011 Issue
July - 2011 / Volume - 3/Issue - 05
( Total Articles =25 )
( Total Articles =25 )
Article No 14
July - 2011 / Volume - 3 / Issue - 05/ Article No - 14 / Research Article
SYNTHESIS AND ANTIMICROBIAL EVALUATION OF CHALCONE SEMICARBAZONE DERIVATIVES
Manmohan Singhal*1, Arindam Paul2
1School of Pharmaceutical Sciences,
Jaipur National University, Jaipur, Rajasthan, India
2G D Memorial College of Pharmacy, Jodhpur, Rajasthan, India
July - 2011 / Volume - 3 / Issue - 05/ Article No - 14 / Research Article
SYNTHESIS AND ANTIMICROBIAL EVALUATION OF CHALCONE SEMICARBAZONE DERIVATIVES
Manmohan Singhal*1, Arindam Paul2
1School of Pharmaceutical Sciences,
Jaipur National University, Jaipur, Rajasthan, India
2G D Memorial College of Pharmacy, Jodhpur, Rajasthan, India
Manmohan Singhal
