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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
IJPRD
November - 2009 / Volume - 1/ Issue - 9
( Total Articles =10 )
( Total Articles =10 )
Article No 3
November - / Volume - 1 / Issue - 9 / Article No -3 / Research Article
STUDY OF PHARMACODYNAMIC INTERACTION BETWEEN DICLOFENAC AND RUMACCT®, A POLYHERBAL FORMULATION IN ALBINO RATS.
Pankaj S. Kothavade1*, Balasaheb D. Siraskar1,
Mahesh D. Burande2 Avinash D. Deshpande1
1Pad. Dr. D. Y. Patil Institute of Pharmaceutical sciences and research, Pimpri, Pune-411018., Maharashtra, India.
2Institute of Pharmaceutical Education and Research, Pune, Maharashtra, India.
E-mail: pankaj_kvd@rediffmail.com
November - / Volume - 1 / Issue - 9 / Article No -3 / Research Article
STUDY OF PHARMACODYNAMIC INTERACTION BETWEEN DICLOFENAC AND RUMACCT®, A POLYHERBAL FORMULATION IN ALBINO RATS.
Pankaj S. Kothavade1*, Balasaheb D. Siraskar1,
Mahesh D. Burande2 Avinash D. Deshpande1
1Pad. Dr. D. Y. Patil Institute of Pharmaceutical sciences and research, Pimpri, Pune-411018., Maharashtra, India.
2Institute of Pharmaceutical Education and Research, Pune, Maharashtra, India.
E-mail: pankaj_kvd@rediffmail.com
Pankaj Kothavade
ABSTRACT
Non-steroidal anti-inflammatory (NSAIDs) are most commonly used in management of acute and chronic pain and inflammation. Combined use of Diclofenac and rumacct a polyherbal formulation to assess anti-inflammatory action with reduced gastric injury caused due to NSAIDs (Diclofenac). The data were interpreted using isobolographic analysis. Carrageenan induced rat paw edema (acute) and cotton pellets induced granuloma (chronic) inflammatory test in albino rats were employed to study interaction of diclofenac and rumacct, and anti-ulcerogenic effect evaluated to reduce gastric injury induced by NSAIDs. In carrageenan induced rat paw method, diclofenac (10 mg/kg) and rumacct (125 and 250 mg/kg) showed significant inhibition of increased rat paw edema. Combination of diclofenac and rumacct (10 + 250, 5 + 125 and 2.5 + 125) mg/kg showed significant (p<0.01) inhibition of paw edema. In cotton pellets induced granuloma, rumacct (125, 250 mg/kg) showed significant inhibition in transudative and prolifarative phase of inflammation. Combination of diclofenac and rumacct (10 + 250, 5 + 125 and 2.5 + 125 mg/kg) showed significant (p<0.01) inhibition in transudative and prolifarative phase of inflammation. In anti-ulcerogenic effect, indomethacin (10 mg/kg) for seven consecutive days induces 100% ulceration, diclofenac showed 72.37% gastric injury while combination of diclofenac and rumacct (10 + 250, 5 + 125 and 2.5 + 125) mg/kg showed gastric injury 41.50%, 17.25% and 8.31% respectively. In conclusion, synergistic interaction occurs between diclofenac and rumacct as per isobologram concept. Co-administration of diclofenac and rumacct may represent new approach to improve anti-inflammatory activity and reduced gastrointestinal side effects.
Keywords: Drug interaction; Anti-inflammatory; Rumacct; NSAIDs; Anti-ulcerogenic effect.
Non-steroidal anti-inflammatory (NSAIDs) are most commonly used in management of acute and chronic pain and inflammation. Combined use of Diclofenac and rumacct a polyherbal formulation to assess anti-inflammatory action with reduced gastric injury caused due to NSAIDs (Diclofenac). The data were interpreted using isobolographic analysis. Carrageenan induced rat paw edema (acute) and cotton pellets induced granuloma (chronic) inflammatory test in albino rats were employed to study interaction of diclofenac and rumacct, and anti-ulcerogenic effect evaluated to reduce gastric injury induced by NSAIDs. In carrageenan induced rat paw method, diclofenac (10 mg/kg) and rumacct (125 and 250 mg/kg) showed significant inhibition of increased rat paw edema. Combination of diclofenac and rumacct (10 + 250, 5 + 125 and 2.5 + 125) mg/kg showed significant (p<0.01) inhibition of paw edema. In cotton pellets induced granuloma, rumacct (125, 250 mg/kg) showed significant inhibition in transudative and prolifarative phase of inflammation. Combination of diclofenac and rumacct (10 + 250, 5 + 125 and 2.5 + 125 mg/kg) showed significant (p<0.01) inhibition in transudative and prolifarative phase of inflammation. In anti-ulcerogenic effect, indomethacin (10 mg/kg) for seven consecutive days induces 100% ulceration, diclofenac showed 72.37% gastric injury while combination of diclofenac and rumacct (10 + 250, 5 + 125 and 2.5 + 125) mg/kg showed gastric injury 41.50%, 17.25% and 8.31% respectively. In conclusion, synergistic interaction occurs between diclofenac and rumacct as per isobologram concept. Co-administration of diclofenac and rumacct may represent new approach to improve anti-inflammatory activity and reduced gastrointestinal side effects.
Keywords: Drug interaction; Anti-inflammatory; Rumacct; NSAIDs; Anti-ulcerogenic effect.
