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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
IJPRD
November - 2009 / Volume - 1/ Issue - 9
( Total Articles =10 )
( Total Articles =10 )
Article No 2
November -2009 / Volume - 1 / Issue - 9 / Article No - 2 / Research Article
PREFORMULATION PARAMETERS CHARACTERIZATION TO DESIGN, DEVELOPMENT AND FORMULATION OF VANCOMYCIN HYDROCHLORIDE TABLETS FOR PSUDOMEMBRANOUS COLITIS
November -2009 / Volume - 1 / Issue - 9 / Article No - 2 / Research Article
PREFORMULATION PARAMETERS CHARACTERIZATION TO DESIGN, DEVELOPMENT AND FORMULATION OF VANCOMYCIN HYDROCHLORIDE TABLETS FOR PSUDOMEMBRANOUS COLITIS
Mr.M.M. Gupta
1Department of Pharmaceutics, Jaipur College of Pharmacy, Tonk Road, Jaipur 302015,India
2 Industrial Pharmacy Research Lab., Department of Pharmacy, S.G.S.I.T.S., Park Road Indore, M.P., India.
2 Industrial Pharmacy Research Lab., Department of Pharmacy, S.G.S.I.T.S., Park Road Indore, M.P., India.
M. M. Gupta* 1, T.R. Saini 2
ABSTRACT
Tablets1 of Vancomycin hydrochloride2, 3 were prepared by direct compression4, 5 method using Lactose (Direct Compression Lactose-21)6, 7 as diluent and Avicel 2006,7 as filler disintegrating agent, whereas Kollidon- CL (Crosslinked polyvinyl pyrollidone)8 was used as superdisintegrant. So before selection of all these excipients as well as direct compression method, the Preformulation study of drug Vancomycin hydrochloride is completed for successful formulation of tablet. The % compressibility was calculated of this drug which is required in the selection of direct compression method and was found 17.5% which suits for this direct compression method. The stability of drug was studied in distilled water and as well as in 0.1N HCl which was required for drug analysis to check release profile without degradation of drug in these solvent and found as such no degradation of drug in water as well as in the 0.1N HCl. The drug -excipient compatibility study is carried by simple physical mixing as well as by Infrared Spectroscopy (IR), and as such no major interaction was found between Vancomycin hydrochloride and all selected excipients (lactose, Avicel, Kollidon, Magnessium stearate and Aerosil). The drug release from tablet was studied by UV spectrophometer so interference of additives during analysis was also checked and as such no interference was found by any excipient in the estimation of drug. The solubility as well as partition coefficient of Vancomycin hydrochloride was also calculated and found 99210 mg / ml and 0.2142 respectively.
Key Words: Vancomycin hydrochloride, % compressibility, compatibility studies, partition coefficient, stability of drug, water, absorbance
Tablets1 of Vancomycin hydrochloride2, 3 were prepared by direct compression4, 5 method using Lactose (Direct Compression Lactose-21)6, 7 as diluent and Avicel 2006,7 as filler disintegrating agent, whereas Kollidon- CL (Crosslinked polyvinyl pyrollidone)8 was used as superdisintegrant. So before selection of all these excipients as well as direct compression method, the Preformulation study of drug Vancomycin hydrochloride is completed for successful formulation of tablet. The % compressibility was calculated of this drug which is required in the selection of direct compression method and was found 17.5% which suits for this direct compression method. The stability of drug was studied in distilled water and as well as in 0.1N HCl which was required for drug analysis to check release profile without degradation of drug in these solvent and found as such no degradation of drug in water as well as in the 0.1N HCl. The drug -excipient compatibility study is carried by simple physical mixing as well as by Infrared Spectroscopy (IR), and as such no major interaction was found between Vancomycin hydrochloride and all selected excipients (lactose, Avicel, Kollidon, Magnessium stearate and Aerosil). The drug release from tablet was studied by UV spectrophometer so interference of additives during analysis was also checked and as such no interference was found by any excipient in the estimation of drug. The solubility as well as partition coefficient of Vancomycin hydrochloride was also calculated and found 99210 mg / ml and 0.2142 respectively.
Key Words: Vancomycin hydrochloride, % compressibility, compatibility studies, partition coefficient, stability of drug, water, absorbance
