ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT
  
 
Aegle marmelos has multiple applications in Indian traditional medicine because of its anti-pyretic, anti-inflammatory, antidiabetic and antimicrobial activities and also have immunosuppressive activity. However, no study on the anti-arthritic activity of Aegle mamrmelos has been reported in vivo. Rheumatoid arthritis (RA) is a systemic autoimmune disease with chronic inflammation characterized by hyperplasia of synovial cells in affected joints, which ultimately leads to the destruction of cartilage and bone. We investigated therapeutic efficacy of Aegle marmelos in treating Rheumatoid Arthritis (RA) using collagen-induced arthritis (CIA) animal model. Arthritis was induced in wistar rats by immunization with bovine type II collagen. CIA rats were treated daily with oral administration of different doses of Methanolic extract of A.marmelos (MAM) beginning on the day after the onset of arthritis (day 21st, the therapeutic treatment) until day 45. The results showed that treatment with MAM markedly reduced paw swelling and arthritic index even in the established CIA. Radiologic and histopathologic changes in the arthritic joints were also significantly reduced in the MAM-treated versus vehicle-treated rats. Moreover, Rheumatoid factor was significantly reduced in MAM treated group in compared to disease control group. Hence, our studies demonstrate safety, and effectiveness of A.marmemlos as an anti-arthritic agent, which makes A.marmelos a strong candidate for further research on rheumatoid arthritis (RA).


Key words:
 
Arthritis, Collagen Induced arthritis, Aegle Marmelos, Cartilage destruction
June 2011 Issue
June - 2011 / Volume - 3/Issue - 04
( Total Articles =30 )
Article No 6
June - 2011 / Volume - 3 / Issue - 04 / / Article No -6 / Research Article

AEGLE MARMELOS SUPPRESSES INFLAMMATION AND CARTILAGE DESTRUCTION IN COLLAGEN-INDUCED ARTHRITIC RAT.

Hardik P. Trivedi1*, Nimish L. Pathak1,
Mahendra G. Gavaniya1, Anjana K. Patel1,
Dr. Harshkant D1. Trivedi, Nitin. M Panchal1
.


1C.U. Shah College of Pharmacy and
Research Wadhwan, Gujarat-363030

Email:
hardik_trivedi23@yahoo.com
Hardik P. Trivedi
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