ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
Docetaxal is a diterpenoid modified from paclitaxal approved by the FDA for the treatment of the ovarian and breast cancer. Due to its low solubility in water, it is clinically administered dissolved in cremophor EL (polyethoxylated caster oil) and ethanol, which causes serious side effect. Inclusion of docetaxal in liposomal formulation has proved to be a good approach to eliminating the vehicle and improving the drug’s antitumor activity. We formulated docetaxel liposomes containing phosphatidylcholine (soybean lecithin), cholesterol and various stabilizers by the dried thin flim hydration method. Particle size analysis, drug content and entrapment efficiency in charged liposomes were strongly affected by the different stabilizers and the results shown neutral (NU-8:2:2) liposomes have the heightst drug content  when compared with charged liposomes and dicetyl phosphate used liposomes (N-7:2:2:1) have the optimum size of the particles and have highest cumulative % drug release. The release kinetics of the neutral and the charged liposomes were studied. All the formulations fallows first order release kinetics and follow case-II transport when it applied to the Korsmeyer -Pepppas Model for the mechanism of thre drug release. The stability of the lyophilized docetaxel liposomes were evaluated after stored at 40C and the room temperature for 3 months. The liposomes stored at 40C were found to be stable for duration of 3 months. Hence it can be concluded that stabilizers like steraylamine and dicetylphosphate along with cholesterol were suitable carrier for the preparation of liposomal docetaxel. 


Key words:
 
Docetaxel, Liposomes, Soybean lecithin, Sterylamine, Dicetylphosphate, cytotoxicity study.
June 2011 Issue
June - 2011 / Volume - 3/Issue - 04
( Total Articles =30 )
Article No 5
June - 2011 / Volume - 3 / Issue - 04 / / Article No - 5 / Research  Article

FORMULATION AND EVALUATION OF LIPOSOMAL DRUG DELIVERY SYSTEM FOR AN ANTICANCER DRUG AND THE STUDY THE EFFECT OF VARIOUS STABILIZERS BASED ON PHYSIOCHEMICAL AND IN VITRO CHARECTERIZATION


Ganesh G. N. K*1, Gowthamarajan K1,
Suresh Kumar R1, Senthil V1, Jawahar N1,
Venkatesh N1, Manjusha. P1, Anindita de1


1Department of Pharmaceutics,
J. S. S. College of Pharmacy, Tamilnadu, India.
E-mail:
ganesh_gnk@rediffmail.com
Ganesh G. N. K
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