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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Article No 6
October -2009 / Volume - 1 /Issue - 8/ Article No - 6 / Research Article
FORMULATION AND EVALUTION OF VENLAFAXINE HCL ENCLOSED IN ALGINATE MICROBEADS PREPARED BY IONTOPHORETIC GELLATION METHOD
B. Bindu Madhavi1*, A. Ravinder Nath1, David Banji2,
R.Ramalingam1, M. Naga Madhu2,
G.Arjun2, V.Sriharsha3
October -2009 / Volume - 1 /Issue - 8/ Article No - 6 / Research Article
FORMULATION AND EVALUTION OF VENLAFAXINE HCL ENCLOSED IN ALGINATE MICROBEADS PREPARED BY IONTOPHORETIC GELLATION METHOD
B. Bindu Madhavi1*, A. Ravinder Nath1, David Banji2,
R.Ramalingam1, M. Naga Madhu2,
G.Arjun2, V.Sriharsha3
IJPRD
B. Bindu Madhavi
1.Faculty of Technology, Osmania University, Hyderabad
2.Nalanda College of Pharmacy, Nalgonda.
3.Dr.Reddy’s laboratories Ltd, Bachupally, Hyderabad
2.Nalanda College of Pharmacy, Nalgonda.
3.Dr.Reddy’s laboratories Ltd, Bachupally, Hyderabad
Abstract
Venlafaxine hydrochloride (VEN) is a representative of a new class of antidepressants. Its higher solubility in water results in burst effect with sudden peak levels of drug in blood. The half lives of VEN and its active metabolite O-desmethyl venlafaxine are 5hr and 11hr respectively. The micro beads were prepared by the ionotropic gelation of sodium alginate in calcium chloride solution. The prepared micro beads were evaluated mainly for the sustain release of the drug apart from the other tests like, % drug encapsulation, particle size and drug polymer compatibility by the FTIR studies. The method had resulted in good encapsulation efficiency and micron sized alginate spheres. The drug release was found to be sustained for 16 hours and was found to follow the Korssmeyer Peppas kinetics.
Key words : Venlafaxine HCl, anti depressant activity, alginate micro beads, sustained release dosage forms.
Venlafaxine hydrochloride (VEN) is a representative of a new class of antidepressants. Its higher solubility in water results in burst effect with sudden peak levels of drug in blood. The half lives of VEN and its active metabolite O-desmethyl venlafaxine are 5hr and 11hr respectively. The micro beads were prepared by the ionotropic gelation of sodium alginate in calcium chloride solution. The prepared micro beads were evaluated mainly for the sustain release of the drug apart from the other tests like, % drug encapsulation, particle size and drug polymer compatibility by the FTIR studies. The method had resulted in good encapsulation efficiency and micron sized alginate spheres. The drug release was found to be sustained for 16 hours and was found to follow the Korssmeyer Peppas kinetics.
Key words : Venlafaxine HCl, anti depressant activity, alginate micro beads, sustained release dosage forms.
