ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
  
The phenyl (thio) semicarbazide derivatives of phthalimido pharmacophores were synthesized and evaluated for their anticonvulsant activity. A series of N4-(4-Methyl Phthalimido) Substituted Phenyl (Thio) Semicarbazide were synthesized by reaction of substituted phenyl (thio) semicarbazide with 4- methyl phthalic anhydride. All the synthesized compounds were characterized on the basis of their IR, 1HNMR and elemental analysis. The anticonvulsant activity of the titled compounds revealed that four compounds 6b (R=2-OCH3), 6d(R=4-CH3), 6e(R=4-OCH3), 6g (R=4-Cl) exhibited highly significant and comparable anticonvulsant activity with respect to standard drug Phenytoin.




Key words:
N4-(4-Methyl Phthalimido) Substituted Phenyl (Thio) Semicarbazide, Phenytoin, Anticonvulsant
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April 2011 Issue
April - 2011 / Volume - 3/Issue - 02
( Total Articles =26 )
Article No 3
April - 2011 / Volume - 3 / Issue - 02 / Article No - 3 / Research Article

SYNTHESIS AND ANTICONVULSANT ACTIVITY OF N4-(4-METHYL PHTHALIMIDO) SUBSTITUTED PHENYL (THIO) SEMICARBAZIDE DERIVATIVES


Bharat Bhushan1*, Amit Girdhar1 ,
Shilpa Ailawadi2,Devender Pathak3

1JCDM College of Pharmacy, Sirsa (HARYANA)
2Saraswati College of Pharmaceutical Sciences,
Gandhinagar GJ
3Rajiv Academy For Pharmacy Nh#2
Delhi-Mathura Bye Pass, Chattikara, Mathura U.P.
E-mail: bharat_krishan@rediffmail.com
Bharat Bhushan