ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
A simple, sensitive, and precise high performance liquid chromatographic method for the analysis of naproxen and pantoprazole has been developed, validated and used for the determination of compounds in commercial pharmaceutical products. The compounds were well separated on a Hypersil BDS C-18 reversed-phase column by use of a mobile phase consisting of 0.1 M sodium acetate (pH 8.2), acetonitrile and methanol (70:20:10 v/v) at a flow rate of 1.0 mL min-1 with detection wavelength at 285 nm. The linearity ranges were 5-70 µg mL-1 for naproxen, and 5-40 µgmL-1 for pantoprazole. The recovery amount was more than 99 %.  The high recovery and low relative standard deviation confirms the suitability of the method for determination of naproxen and pantoprazole in pharmaceutical dosage forms.


Key words:
Naproxen, Pantoprazole, HPLC

Article No 24
February - 2011 / Volume - 2 / Issue - 12 / Article No - 24 / Research Article


DEVELOPMENT AND VALIDATION OF  RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF NAPROXEN AND PANTOPRAZOLE IN PHARMACEUTICAL DOSAGE FORM

Rajnish Kumar1*,

Pinderjit Singh1, Harinder Singh1

1State Food, Drug and Excise Laboratory,
Punjab, Sector - 11 D, Chandigarh, India
                                                                                   
Email:
rajnishthaper@gmail.com
Rajnish Kumar
February - 2011 / Volume - 2/Issue - 12
( Total Articles =25 )
February 2011 Issue
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