Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Now a days as very few drugs are coming out of research and development and already existing drugs are suffering the problem of resistance due to their irrational use specifically in case of drugs like antibiotics. Hence, change in the operation is a suitable and optimized way to make the some drug more effective by slight alteration in the drug delivery. Sustained Release is also providing promising way to decrease the side effect of drug by preventing the fluctuation of the therapeutic concentration of the drug in the body. This article contains the basic information regarding sustained-release formulation and also the different types of the same.
Key words: Sustained-release, Conventional tablet, Oral controlled release system, Matrix tablet.
Article No 16
February - 2011 / Volume - 2 / Issue - 12 / Article No - 16 / ReviewArticle
SUSTAINED RELEASE DRUG DELIVERY SYSTEM : A REVIEW
Shalin A. Modi1*, P. D. Gaikwad1,
V. H. Bankar1, S. P. Pawar1
1P.S.G.V.P.Mís College of Pharmacy, Shahada,
Dist-Nandurbar, Maharashtra-425 409
February - 2011 / Volume - 2/Issue - 12
( Total Articles =25 )
February 2011 Issue