Copyright © 2009 by "International Journal of Pharmaceutica Research and Development" · All Rights reserved · E-Mail: info@ijprd.com
HOW TO PREPARE
YOUR PAPER
YOUR PAPER
Past Issues
March 2009
April 2009
May 2009
June 2009
July 2009
August 2009
September 2009
October 2009
November 2009
December 2009
March 2009
April 2009
May 2009
June 2009
July 2009
August 2009
September 2009
October 2009
November 2009
December 2009
Online Since : March 2009
Only 10 Articles will be Published in Each Issues
TODAY IS
INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
IJPRD
October - 2009 / Volume - 1/Issue -8
( Total Articles =10 )
( Total Articles =10 )
Article No 1
October -2009 / Volume - 1 /Issue - 8/ Article No - 1 / Research Article
DEVELOPMENT AND VALIDATION OF DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF ENTACAPONE IN PHARMACEUTICAL FORMULATION
Shailesh K. Koradia*1, Ashwin S. Agola2,
Nurudin P. Jivani1, Ravi A. Manek1 and
Shivanand Pandey1
October -2009 / Volume - 1 /Issue - 8/ Article No - 1 / Research Article
DEVELOPMENT AND VALIDATION OF DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF ENTACAPONE IN PHARMACEUTICAL FORMULATION
Shailesh K. Koradia*1, Ashwin S. Agola2,
Nurudin P. Jivani1, Ravi A. Manek1 and
Shivanand Pandey1
Mr.Shailesh Koradia
1Smt. R. B. Patel Mahila Pharmacy College, Atkot, Rajkot, Gujarat, INDIA.
2N. R. Vekariya Pharmacy College, Junagadh, Gujarat, INDIA.
Email ID: shailesh_koradia@yahoo.com
2N. R. Vekariya Pharmacy College, Junagadh, Gujarat, INDIA.
Email ID: shailesh_koradia@yahoo.com
ABSTRACT
A rapid, precise, accurate and specific first-order derivative spectrophotometric method was developed for the determination of Entacapone in pharmaceutical formulation. The technique was applied using 0.01M NaOH as diluent. The first-order derivative spectra were obtained at N = 10, ?l = 4.0 nm, and determination were made at 375.0 nm. The method showed high specificity in the presence of formulation excipients and good linearity in the concentration range of 2-25 µg/mL with correlation coefficient 0.9964. The detection limit and quantitation limit were found to be 0.42 µg/mL and 1.28 µg/mL, respectively. The recovery ranged between 96.11 and 100.61%. The proposed method is easy to apply, low-cost, does not use polluting reagents and require relatively inexpensive instruments.
Key words: Entacapone, first-order derivative, method validation, tablets
A rapid, precise, accurate and specific first-order derivative spectrophotometric method was developed for the determination of Entacapone in pharmaceutical formulation. The technique was applied using 0.01M NaOH as diluent. The first-order derivative spectra were obtained at N = 10, ?l = 4.0 nm, and determination were made at 375.0 nm. The method showed high specificity in the presence of formulation excipients and good linearity in the concentration range of 2-25 µg/mL with correlation coefficient 0.9964. The detection limit and quantitation limit were found to be 0.42 µg/mL and 1.28 µg/mL, respectively. The recovery ranged between 96.11 and 100.61%. The proposed method is easy to apply, low-cost, does not use polluting reagents and require relatively inexpensive instruments.
Key words: Entacapone, first-order derivative, method validation, tablets
