Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Emulsion in gel have emerged as one of the most interesting topical drug delivery system as it has dual release control system i.e. emulsion and gel. Also the stability of emulsion is increased when it is incorporated in gel. Miconazole nitrate, a fungicidal, is effective for the local as well as Systemic fungal infections. The objective of this project was to develop an emulsion based gel for control delivery for miconazole to treat local as well as systemic fungal infections. In present work we prepare emulsion and then incorporated in Carbopol gel. The prepared formulation was evaluated on basis of pH, spreadability, Viscosity, drug content, in vitro release and Stability Studies. The result of studies reveled that the optimized batch shows 94.80% release in 24 hours and stable for around three months. The microbial assay was also performed using fungal strain and compared with marketed product, the result shows 39.7% inhibition of optimized batch where as marketed preparation shows only 28.3% inhibition. Hence it can be concluded that emulsion based system is more effective system for controlled delivery of antifungal agent(s).
Key words: Emulsion, Gel, Emulgel, Miconazole nitrate, Topical Drug Delivery
Article No 3
February - 2011 / Volume - 2 / Issue - 12 / Article No - 3 / Research Article
DEVELOPMENT OF ANTIFUNGAL EMULSION BASED GEL FOR TOPICAL FUNGAL INFECTION(S).
Ankur Jain1*, Piyusha Deveda1,
Naveen Vyas1, Jitendra Chauhan1,
Hemant Khambete1, Dr.Sanjay Jain1
1Smriti College of Pharmaceutical Education,
4/1 Pipliya Kumar Kakkad, Mayakheri road
February - 2011 / Volume - 2/Issue - 12
( Total Articles =25 )
February 2011 Issue