Copyright © 2009 by "International Journal of Pharmaceutica Research and Development" · All Rights reserved · E-Mail: info@ijprd.com
HOW TO PREPARE
YOUR PAPER
YOUR PAPER
Past Issues
March 2009
April 2009
May 2009
June 2009
July 2009
August 2009
September 2009
October 2009
November 2009
December 2009
March 2009
April 2009
May 2009
June 2009
July 2009
August 2009
September 2009
October 2009
November 2009
December 2009
Online Since : March 2009
Only 10 Articles will be Published in Each Issues
TODAY IS
INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Article No 09
September -2009 / Volume -1 / Issue - 7/Article No - 10/ Research Article
AN APPROACH TOWARDS TASTE ABATEMENT OF ROXITHROMYCIN
ABHAY N. PADALKAR*1, SADHANA R.
SHAHI2,
YOGANAND K. UDAVANT2,
RAVINDRA J SALUNKE 2, B.S. KUCHEKAR3.
September -2009 / Volume -1 / Issue - 7/Article No - 10/ Research Article
AN APPROACH TOWARDS TASTE ABATEMENT OF ROXITHROMYCIN
ABHAY N. PADALKAR*1, SADHANA R.
SHAHI2,
YOGANAND K. UDAVANT2,
RAVINDRA J SALUNKE 2, B.S. KUCHEKAR3.
Mr. Padalkar Abhay
1Executive, Concept Pharmaceuticals, Aurangabad,Maharashtra,India
2Government College of Pharmacy, Aurangabad,Maharashtra,India
3Maharastra Institute of Pharmacy, Pune,,Maharashtra,India
2Government College of Pharmacy, Aurangabad,Maharashtra,India
3Maharastra Institute of Pharmacy, Pune,,Maharashtra,India
ABSTRACT
The present work focuses on the formulation and evaluation of tasteless complex of roxithromycin using an ion exchange resin Doshion P544(R). The batch process was selected for the complexation. The effect of complexation time, temperature and pH on roxithromycin loading is reported. The drug-activated resin showed efficient drug loading in the ratio of 1: 3. The release of roxithromycin from drug resin complex (DRC) was studied at salivary and gastric pH. Drug complexation was enhanced with pH (from 1.2 to 9). Drug release from DRC at salivary pH was insufficient to impart the bitter taste. Volunteers also rated the complex as agreeable. Complete drug release was observed at gastric pH in 1 hour. The ease and the simplicity of the technique of complexation makes ion exchange resin Doshion P544(R) a possible choice for economical and effective taste abatement of roxithromycin.
Key worlds: Doshion P544(R), Ion exchange resins, Roxithromycin, Drug resin complex
The present work focuses on the formulation and evaluation of tasteless complex of roxithromycin using an ion exchange resin Doshion P544(R). The batch process was selected for the complexation. The effect of complexation time, temperature and pH on roxithromycin loading is reported. The drug-activated resin showed efficient drug loading in the ratio of 1: 3. The release of roxithromycin from drug resin complex (DRC) was studied at salivary and gastric pH. Drug complexation was enhanced with pH (from 1.2 to 9). Drug release from DRC at salivary pH was insufficient to impart the bitter taste. Volunteers also rated the complex as agreeable. Complete drug release was observed at gastric pH in 1 hour. The ease and the simplicity of the technique of complexation makes ion exchange resin Doshion P544(R) a possible choice for economical and effective taste abatement of roxithromycin.
Key worlds: Doshion P544(R), Ion exchange resins, Roxithromycin, Drug resin complex
