Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
December - 2010 / Volume - 2/Issue - 10
( Total Articles =17 )
December 2010 Issue
Article No 11
December - 2010 / Volume - 2 / Issue - 10 / Article No - 10 / Research Article
FORMULATION AND EVALUATION OF CEFOTAXIME SODIUM MICROCAPSULES
M.Naga Madhu1, B.Bindu Madhavi1,
G.Arjun1, B.Pradeep1, David Banji1
1Department of Pharmaceutics,
Nalanda College of Pharmacy, Nalgonda.
Microbial infections are the vast growing disorders in the world. Most of the drugs are used to treat these disorders. Our research was focused mainly on treating the microbial diaseases by formulating the drug cefotaxime sodium into microcapsules for its sustained drug release. Cefotaxime sodium drug has short half-life. The present dosage from was developed to reduce the frequency of dose administration, ease of dose adjustment & improve patient compliance. In this study sustained release microcapsules were prepared by solvent evaporation technique using ethylcellulose as polymer. Preformulation compatability studies & evaluation studies were performed.
Key words: Cefotaxime Sodium, Ethyl Cellulose, Microencapsulation, Sustained Release.