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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Article No 6
September -2009 / Volume - 1 / Issue - 7/ Article No - 6 / Research Article
ANTIDIABETIC AND ANTIOXIDATIVE EFFECTS OF AQUEOUS EXTRACT OF SEED OF PSORALEA CORYLIFOLIA (SOMRAJI) AND SEED OF TRIGONELLA FOENUM-GRAECUM L. (METHI) IN SEPARATE AND COMPOSITE MANNER IN STREPTOZOTOCIN-INDUCED DIABETIC MALE ALBINO RAT
DEBIDAS GHOSH, 1* TUSHAR KANTI BERA, 1,
2 KAUSIK CHATTERJEE, 1
KAZI MONJUR ALI, 1 DEBASIS DE 1
September -2009 / Volume - 1 / Issue - 7/ Article No - 6 / Research Article
ANTIDIABETIC AND ANTIOXIDATIVE EFFECTS OF AQUEOUS EXTRACT OF SEED OF PSORALEA CORYLIFOLIA (SOMRAJI) AND SEED OF TRIGONELLA FOENUM-GRAECUM L. (METHI) IN SEPARATE AND COMPOSITE MANNER IN STREPTOZOTOCIN-INDUCED DIABETIC MALE ALBINO RAT
DEBIDAS GHOSH, 1* TUSHAR KANTI BERA, 1,
2 KAUSIK CHATTERJEE, 1
KAZI MONJUR ALI, 1 DEBASIS DE 1
1Dept. of Bio-Medical Laboratory Science and Management
Vidyasagar University,Midnapore-721 102,West Bengal, India
2 Pharmaceutical Division, Southern Health Improvement Samity (SHIS)
Bhangar, South 24 Paraganas,West Bengal, India
E- mail- debidas_ghosh@yahoo.co.in
Vidyasagar University,Midnapore-721 102,West Bengal, India
2 Pharmaceutical Division, Southern Health Improvement Samity (SHIS)
Bhangar, South 24 Paraganas,West Bengal, India
E- mail- debidas_ghosh@yahoo.co.in
Mr.Ghosh Debidas
ABSTRACT
Background: In modern medicine, no satisfactory effective therapy is still available to cure diabetes mellitus. Though, synthetic drugs are used for the management of diabetes mellitus but there are several drawbacks. The attributed antihyperglycemic effects of many traditional plants are due to their ability for the management of diabetes mellitus.
Aim: To find out the effect of the aqueous extract of seed of Somraji (Psoralea corylifolia) and seed of Methi (Trigonella foenum-graecum L.) for the management of streptozotocin-induced diabetes.
Methods: Aqueous extracts of seeds of Somraji and Methi were tested in streptozotocin-induced diabetic rat. Extract was administered orally either in separate or in composite (1:1) manner at the dose of 20 mg/0.5ml water/100gm body weight/day for 21 days. Its effects on fasting blood glucose level, activities of key carbohydrate metabolic enzymes like hexokinase, glucose-6-phosphatase and glucose-6-phosphate dehydrogenase and antioxidant enzymes like catalase, peroxidase and superoxide dismutase along with the lipid peroxidation level in hepatic tissue and serum transaminase activity were assessed.
Results: Treatment of aqueous extract of above plants parts resulted a significant recovery in the activities of above mention enzymes along with correction in fasting blood glucose level in composite extract treated diabetic group than the individual extract treated diabetic group. The corrective effects produced by extract were compared with the standard antidiabetic drug, metformin.
Conclusion: Composite extract of above plants parts have more potential antidiabetogenic activities than separate extract.
Keywords: Psoralea corylifolia, Trigonella foenum-graecum L., Antidiabetic, Antioxidative
Background: In modern medicine, no satisfactory effective therapy is still available to cure diabetes mellitus. Though, synthetic drugs are used for the management of diabetes mellitus but there are several drawbacks. The attributed antihyperglycemic effects of many traditional plants are due to their ability for the management of diabetes mellitus.
Aim: To find out the effect of the aqueous extract of seed of Somraji (Psoralea corylifolia) and seed of Methi (Trigonella foenum-graecum L.) for the management of streptozotocin-induced diabetes.
Methods: Aqueous extracts of seeds of Somraji and Methi were tested in streptozotocin-induced diabetic rat. Extract was administered orally either in separate or in composite (1:1) manner at the dose of 20 mg/0.5ml water/100gm body weight/day for 21 days. Its effects on fasting blood glucose level, activities of key carbohydrate metabolic enzymes like hexokinase, glucose-6-phosphatase and glucose-6-phosphate dehydrogenase and antioxidant enzymes like catalase, peroxidase and superoxide dismutase along with the lipid peroxidation level in hepatic tissue and serum transaminase activity were assessed.
Results: Treatment of aqueous extract of above plants parts resulted a significant recovery in the activities of above mention enzymes along with correction in fasting blood glucose level in composite extract treated diabetic group than the individual extract treated diabetic group. The corrective effects produced by extract were compared with the standard antidiabetic drug, metformin.
Conclusion: Composite extract of above plants parts have more potential antidiabetogenic activities than separate extract.
Keywords: Psoralea corylifolia, Trigonella foenum-graecum L., Antidiabetic, Antioxidative
