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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Article No 5
September -2009 / Volume - 1 / Issue - 7/Article No - 5 / Research Article
DEVELOPMENT AND VALIDATION OF HPTLC METHOD TO DETECT 3-HYDROXY ANDROSTANE [16,17-C](6’METHYL, 2’-1-HYDROXY -ISOPROPENE-1-YL) 4,5,6 H PYRAN IN POLYHERBAL FORMULATION
SAPANA S. KAMBLE1* , VARSHA M. JADHAV1,
VILASRAO J. KADAM1
September -2009 / Volume - 1 / Issue - 7/Article No - 5 / Research Article
DEVELOPMENT AND VALIDATION OF HPTLC METHOD TO DETECT 3-HYDROXY ANDROSTANE [16,17-C](6’METHYL, 2’-1-HYDROXY -ISOPROPENE-1-YL) 4,5,6 H PYRAN IN POLYHERBAL FORMULATION
SAPANA S. KAMBLE1* , VARSHA M. JADHAV1,
VILASRAO J. KADAM1
Miss Kamble Sapna.
Department of Quality Assurance, Bharati Vidyapeeth’s College of Pharmacy, Sector 08, CBD Belapur, Navi-Mumbai - 400 614, India
E-mail: sapana_ak@rediffmail.com
E-mail: sapana_ak@rediffmail.com
ABSTRACT
3-hydroxy androstane [16,17-C](6’methyl, 2’-1-hydroxy -isopropene-1-yl) 4,5,6 H pyran is one of the phytoconstituent present in Syzygium cumini Linn. is known for its hypoglycemic activity from ancient times. In the present study an attempt has been made to develop a HPTLC method for quantitative estimation of 3-hydroxy androstane [16,17-C](6’methyl, 2’-1-hydroxy -isopropene-1-yl) 4,5,6 H pyran in different marketed antidiabetic polyherbal formulations. This HPTLC method was found to be reproducible, accurate and detect 3-hydroxy androstane [16,17-C](6’methyl, 2’-1-hydroxy -isopropene-1-yl) 4,5,6 H pyran at nanogram level. The developed HPTLC method would be an important tool in the quality control method of polyherbal formulations.
Keywords Syzygium cumini, HPTLC, polyherbal formulation, Validation.
3-hydroxy androstane [16,17-C](6’methyl, 2’-1-hydroxy -isopropene-1-yl) 4,5,6 H pyran is one of the phytoconstituent present in Syzygium cumini Linn. is known for its hypoglycemic activity from ancient times. In the present study an attempt has been made to develop a HPTLC method for quantitative estimation of 3-hydroxy androstane [16,17-C](6’methyl, 2’-1-hydroxy -isopropene-1-yl) 4,5,6 H pyran in different marketed antidiabetic polyherbal formulations. This HPTLC method was found to be reproducible, accurate and detect 3-hydroxy androstane [16,17-C](6’methyl, 2’-1-hydroxy -isopropene-1-yl) 4,5,6 H pyran at nanogram level. The developed HPTLC method would be an important tool in the quality control method of polyherbal formulations.
Keywords Syzygium cumini, HPTLC, polyherbal formulation, Validation.
