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ABSTRACT
Ibuprofen, a non-steroidal anti-inflammatory drug was formulated as microspheres by using ethylcellulose as carrier. These ethylcellulose microspheres were prepared by the solvent evaporation method. The prepared microspheres were subjected to various evaluation and invitro release studies. Highest percentage of loading was obtained by increasing the amount of ibuprofen with respect to polymer. The particle sizes of the prepared microspheres were determined by optical microscopy and SEM analysis. The prepared microspheres had good spherical geometry with smooth surface as evidence by SEM. The invitro release studies showed that ibuprofen microspheres of 1:2 ratios showed better sustained effect over a period of 8 hours.
Key words: Ibuprofen, Ethyl cellulose, Microspheres.
Ibuprofen, a non-steroidal anti-inflammatory drug was formulated as microspheres by using ethylcellulose as carrier. These ethylcellulose microspheres were prepared by the solvent evaporation method. The prepared microspheres were subjected to various evaluation and invitro release studies. Highest percentage of loading was obtained by increasing the amount of ibuprofen with respect to polymer. The particle sizes of the prepared microspheres were determined by optical microscopy and SEM analysis. The prepared microspheres had good spherical geometry with smooth surface as evidence by SEM. The invitro release studies showed that ibuprofen microspheres of 1:2 ratios showed better sustained effect over a period of 8 hours.
Key words: Ibuprofen, Ethyl cellulose, Microspheres.
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October - 2010 / Volume - 2/Issue - 8
( Total Articles =20 )
( Total Articles =20 )
October 2010 Issue
Article No 19
October - 2010 / Volume - 2 / Issue - 8 / Article No - 19 / Research Article
PREPARATION AND EVALUATION OF ETHYL CELLULOSE MICROSPHERES OF IBUPROFEN FOR SUSTAINED DRUG DELIVERY.
T.Sudhamani*, K. Noveenkumar reddy,
V.R. Ravi Kumar, R.Revathi, V. Ganesan
1The Erode College of Pharmacy & Research Institute,
Erode - 638112, Tamil Nadu, India,
Email:tsmkrishv28@yahoo.com
October - 2010 / Volume - 2 / Issue - 8 / Article No - 19 / Research Article
PREPARATION AND EVALUATION OF ETHYL CELLULOSE MICROSPHERES OF IBUPROFEN FOR SUSTAINED DRUG DELIVERY.
T.Sudhamani*, K. Noveenkumar reddy,
V.R. Ravi Kumar, R.Revathi, V. Ganesan
1The Erode College of Pharmacy & Research Institute,
Erode - 638112, Tamil Nadu, India,
Email:tsmkrishv28@yahoo.com
T. Sudhamani
