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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Article No 2
September -2009 / Volume - 1 / Issue - 7/Article No - 2 / Research Article
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF PROMETHAZINE HCL WITH MASKED BITTER TASTE
September -2009 / Volume - 1 / Issue - 7/Article No - 2 / Research Article
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF PROMETHAZINE HCL WITH MASKED BITTER TASTE
ABSTRACT
The objective of this study was to prepare fast dissolving tablets which can rapidly disintegrate in the saliva using taste-masked granules of drugs with a bitter taste, Promethazine HCl (PM HCl). The taste masked granules were prepared using gastro erodible aminoalkyl methacrylate copolymers (Eudragit E-100) by extrusion method. Fast dissolving tablets were prepared using taste-masked granules and a mixture of excipients containing optimized level of Microcrystalline cellulose (Avicel PH-101) and starch. The effect of various superdisintegrants [Crospovidone (Polyplasdone XL), Sodium Starch Glycolate (Primogel), Croscarmellose sodium (Ac-Di-Sol)] was also studied. The tablets were directly compressed using rotary press tableting machine. The prepared tablets were evaluated for taste, crushing strength, disintegration time (DT) and dissolution. Evaluation of taste masked granule of PM HCl was confirmed by UV spectrophotometric method as well as sensory evaluation study. The dissolution rate was significantly improved with FDT formulated with taste masked granules of PM HCl as compared with unmasked granules. This could be accounted to the effect of Eudragit E-100 on the dissolution profile of PM HCl and also aiding in masking the bitter taste.
Keywords: Taste masking, Promethazine HCL, Eudragit E 100, Fast dissolving tablet.
The objective of this study was to prepare fast dissolving tablets which can rapidly disintegrate in the saliva using taste-masked granules of drugs with a bitter taste, Promethazine HCl (PM HCl). The taste masked granules were prepared using gastro erodible aminoalkyl methacrylate copolymers (Eudragit E-100) by extrusion method. Fast dissolving tablets were prepared using taste-masked granules and a mixture of excipients containing optimized level of Microcrystalline cellulose (Avicel PH-101) and starch. The effect of various superdisintegrants [Crospovidone (Polyplasdone XL), Sodium Starch Glycolate (Primogel), Croscarmellose sodium (Ac-Di-Sol)] was also studied. The tablets were directly compressed using rotary press tableting machine. The prepared tablets were evaluated for taste, crushing strength, disintegration time (DT) and dissolution. Evaluation of taste masked granule of PM HCl was confirmed by UV spectrophotometric method as well as sensory evaluation study. The dissolution rate was significantly improved with FDT formulated with taste masked granules of PM HCl as compared with unmasked granules. This could be accounted to the effect of Eudragit E-100 on the dissolution profile of PM HCl and also aiding in masking the bitter taste.
Keywords: Taste masking, Promethazine HCL, Eudragit E 100, Fast dissolving tablet.
Mr.Mahamuni Sachin
1Government College of Pharmacy, Aurangabad,Maharashtra,India
SACHIN B. MAHAMUNI1*, SADHANA R. SHAHI1, NANDAKISHOR V. SHINDE1, GAURAV R. AGRAWAL1.
