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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Article No 1
September -2009 / Volume - 1 / Issue - 7/Article No - 1 / Research Article
DESIGN AND EVALUATION OF AMLODIPINE BESILATE TRANSDERMAL PATCHES CONTAINING FILM FORMER
HEMANGI J. PATEL1*, JITENDRA S. PATEL1,
B. G. DESAI2, KEYUR D. PATEL3
September -2009 / Volume - 1 / Issue - 7/Article No - 1 / Research Article
DESIGN AND EVALUATION OF AMLODIPINE BESILATE TRANSDERMAL PATCHES CONTAINING FILM FORMER
HEMANGI J. PATEL1*, JITENDRA S. PATEL1,
B. G. DESAI2, KEYUR D. PATEL3
September - 2009 / Volume - 7
( Total Articles =09 )
( Total Articles =09 )
IJPRD
Mrs.Patel Hemangi
1Department of Pharmaceutics,
H.N. Shukla pharmacy College, Rajkot-360002,India.
2KLES’S College of Pharmacy, Bangalore-560010,India
3Visveswarpura Institute of Pharmaceutical Sciences, Bangalore,India
Email: jiturx@gmail.com
H.N. Shukla pharmacy College, Rajkot-360002,India.
2KLES’S College of Pharmacy, Bangalore-560010,India
3Visveswarpura Institute of Pharmaceutical Sciences, Bangalore,India
Email: jiturx@gmail.com
ABSTRACT
Matrix type Transdermal drug delivery system of Amlodipine besilate, an antihypertensive drug were prepared using different polymers like Carbopol 934, 940, HydroxyPropyl Methyl Cellulose and Eudragit L100 in varied ratios. The present study aims to formulate and evaluate Transdermal drug delivery for sustained release of Amlodipine besilate. Physicochemical parameter were characterized. The permeability studies indicates that the drug is suitable for Transdermal drug delivery. The patches were evaluated for various parameters like Thickness, Water-Vapor Permeability, Tensile Strength, Drug Content, Diffusion and Dissolution studies. The patches were further evaluated by DSC and SEM, to ensure uniform distribution of the drug and compatibility of drug with polymer. The Optimized formulation containing Carbopol 934: Eudragit L100 (3:7), with enhancer Hyaluronidase showed 84% drug release after 24 hours. Higuchi and Peppa’s models were used for optimizing the formulation.
Key words: Transdermal patches; Sustained release; Carbopol; Amlodipine Besilate;
Matrix type Transdermal drug delivery system of Amlodipine besilate, an antihypertensive drug were prepared using different polymers like Carbopol 934, 940, HydroxyPropyl Methyl Cellulose and Eudragit L100 in varied ratios. The present study aims to formulate and evaluate Transdermal drug delivery for sustained release of Amlodipine besilate. Physicochemical parameter were characterized. The permeability studies indicates that the drug is suitable for Transdermal drug delivery. The patches were evaluated for various parameters like Thickness, Water-Vapor Permeability, Tensile Strength, Drug Content, Diffusion and Dissolution studies. The patches were further evaluated by DSC and SEM, to ensure uniform distribution of the drug and compatibility of drug with polymer. The Optimized formulation containing Carbopol 934: Eudragit L100 (3:7), with enhancer Hyaluronidase showed 84% drug release after 24 hours. Higuchi and Peppa’s models were used for optimizing the formulation.
Key words: Transdermal patches; Sustained release; Carbopol; Amlodipine Besilate;
