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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
August - 2010 / Volume - 2/Issue - 6
( Total Articles =15 )
( Total Articles =15 )
August 2010 Issue
ABSTRACT
Vagina is one of the best routes for drugs administration like contraceptive steroids, metronidazole, anti-retroviral, etc. An intra-vaginal controlled-release drug delivery system is an effective means for achieving a continuous delivery of therapeutic agents, not only the systemically active drugs, such as contraceptive steroids, but also the locally active drugs, such as metronidazole and other drugs like Zidovudine, Lamivudine, etc. This continuous “infusion” of drugs through the vaginal mucosa can prevent the possibility of hepato-gastrointestinal first-pass metabolism gastric irritation of drugs and fluctuation of dosaging interval. The advantage of intra-vaginal controlled drug administration over conventional/traditional oral administration is the drug absorbed systemically, because due to the presence of dense network of blood vessels in vaginal wall. At last, the present article concluded that the vaginal drug delivery is the best in comparison of other.
Key words: intraviginal,anti-retroviral, metronidazole,Zidovudine, Lamivudine,vaginal drug delivery.
Vagina is one of the best routes for drugs administration like contraceptive steroids, metronidazole, anti-retroviral, etc. An intra-vaginal controlled-release drug delivery system is an effective means for achieving a continuous delivery of therapeutic agents, not only the systemically active drugs, such as contraceptive steroids, but also the locally active drugs, such as metronidazole and other drugs like Zidovudine, Lamivudine, etc. This continuous “infusion” of drugs through the vaginal mucosa can prevent the possibility of hepato-gastrointestinal first-pass metabolism gastric irritation of drugs and fluctuation of dosaging interval. The advantage of intra-vaginal controlled drug administration over conventional/traditional oral administration is the drug absorbed systemically, because due to the presence of dense network of blood vessels in vaginal wall. At last, the present article concluded that the vaginal drug delivery is the best in comparison of other.
Key words: intraviginal,anti-retroviral, metronidazole,Zidovudine, Lamivudine,vaginal drug delivery.
Lalit Kumar
Article No 3
August - 2010 / Volume - 2 / Issue - 6 / Article No -3 / Review Article
ADVANTAGES OF INTRA-VAGINAL DRUG DELIVERY SYSTEM: AN OVERVIEW
Lalit Kumar1,* and Ruchi Verma1
1Sikkim Manipal Instituteof Medical Sciences,
Sikkim Manipal University,
Gangtok, Sikkim, India - 737102
Email:lalitkumar_pharma@yahoo.co.in
August - 2010 / Volume - 2 / Issue - 6 / Article No -3 / Review Article
ADVANTAGES OF INTRA-VAGINAL DRUG DELIVERY SYSTEM: AN OVERVIEW
Lalit Kumar1,* and Ruchi Verma1
1Sikkim Manipal Instituteof Medical Sciences,
Sikkim Manipal University,
Gangtok, Sikkim, India - 737102
Email:lalitkumar_pharma@yahoo.co.in