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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
August - 2010 / Volume - 2/Issue - 6
( Total Articles =15 )
( Total Articles =15 )
August 2010 Issue
Article No 1
August - 2010 / Volume - 2 / Issue - 6 / Article No - 1 / Research Article
SINGLE BLIND PLACEBO CONTROLLED STUDY OF ISPAGHULA IN HYPERLIPIDEMIA
Shah Murad1*, Taqadus Abbas2,
Amar Lal Ghurbakhshani3,
Samina Karim4, Manzoor Ahmad Unar5,
Moosa Khan6, Ghazi Mahmood7, Aijaz Fatima8
1Professor, Pharmacology, Lahore Medical and Dental College, Lahore
2Associate Professor, ENT, Ghurki Trust Teaching Hospital, LM&DC, Lahore
3Assistant Professor, Physiology, Chandka Medical College, Larkana
4Associate Professor, Pharmacology, SIMS, Lahore
5Assistant Professor, Pharmacology, CMC, Larkana
6Assistant Professor, Pharmacology, BMSI, JPMC, Karachi
7Senior Registrar, ENT, GTTH, LM&DC, Lahore
8Lecturer, Pharmacology, LM&DC, Lahore
Email: shahmurad65@gmail.com
August - 2010 / Volume - 2 / Issue - 6 / Article No - 1 / Research Article
SINGLE BLIND PLACEBO CONTROLLED STUDY OF ISPAGHULA IN HYPERLIPIDEMIA
Shah Murad1*, Taqadus Abbas2,
Amar Lal Ghurbakhshani3,
Samina Karim4, Manzoor Ahmad Unar5,
Moosa Khan6, Ghazi Mahmood7, Aijaz Fatima8
1Professor, Pharmacology, Lahore Medical and Dental College, Lahore
2Associate Professor, ENT, Ghurki Trust Teaching Hospital, LM&DC, Lahore
3Assistant Professor, Physiology, Chandka Medical College, Larkana
4Associate Professor, Pharmacology, SIMS, Lahore
5Assistant Professor, Pharmacology, CMC, Larkana
6Assistant Professor, Pharmacology, BMSI, JPMC, Karachi
7Senior Registrar, ENT, GTTH, LM&DC, Lahore
8Lecturer, Pharmacology, LM&DC, Lahore
Email: shahmurad65@gmail.com
Dr. Shah Murad
ABSTRACT
Study was planned to examine the effects of ispaghula on Serum Total Cholesterol and LDL-Cholesterol the design used is Single blind placebo controlled study, The study was to be conducted at department of Pharmacology and therapeutics at Basic Medical Sciences Institute , Jinnah Postgraduate Medical Centre, Karachi, from January 2006 to July 2006. In this Forty hyperlipidemic patients to be included, among which 20 patients were on placebo as control group, and 20 were on ispaghula, 3 gram daily, in divided doses for the period of three months. Patients with peptic ulcer, renal disease, hepatic disease, hypothyroidism, diabetes mellitus, and alcoholism were excluded from the study. Serum total cholesterol was calculated by enzymatic calorimeter method. Serum LDL-cholesterol was calculated by formula: LDL-Cholesterol = Total Cholesterol-(Triglycerides/5 +HDL-Cholesterol described by Delong et al (1986)12 and Beamount et al (1970).13 Data were expressed as the mean ± SD and “t” test was applied to determine statistical significance as the difference. A probability value of <0.05 was the limit of significance, the expected conclusion of study is that the ispaghula decreases the serum total cholesterol and LDL-Cholesterol in hyperlipidemic patients
Key words: Ispaghula. Hyperlipidemia. LDL-Cholesterol. Serum total cholesterol. Coronary heart disease.
Study was planned to examine the effects of ispaghula on Serum Total Cholesterol and LDL-Cholesterol the design used is Single blind placebo controlled study, The study was to be conducted at department of Pharmacology and therapeutics at Basic Medical Sciences Institute , Jinnah Postgraduate Medical Centre, Karachi, from January 2006 to July 2006. In this Forty hyperlipidemic patients to be included, among which 20 patients were on placebo as control group, and 20 were on ispaghula, 3 gram daily, in divided doses for the period of three months. Patients with peptic ulcer, renal disease, hepatic disease, hypothyroidism, diabetes mellitus, and alcoholism were excluded from the study. Serum total cholesterol was calculated by enzymatic calorimeter method. Serum LDL-cholesterol was calculated by formula: LDL-Cholesterol = Total Cholesterol-(Triglycerides/5 +HDL-Cholesterol described by Delong et al (1986)12 and Beamount et al (1970).13 Data were expressed as the mean ± SD and “t” test was applied to determine statistical significance as the difference. A probability value of <0.05 was the limit of significance, the expected conclusion of study is that the ispaghula decreases the serum total cholesterol and LDL-Cholesterol in hyperlipidemic patients
Key words: Ispaghula. Hyperlipidemia. LDL-Cholesterol. Serum total cholesterol. Coronary heart disease.