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Online Since : March 2009
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
ABSTRACT
The present investigation concerns the development of the floating matrix tablets of Salbutamol Sulphate. Tablets were prepared by wet granulation method and were characterized using the official method. Hydroxypropyl methylcellulose was used as a release retardant material. Sodium bicarbonate and Citric acid was incorporated as a gas-generating agent. The effects of citric acid on drug release profile, floating properties and matrix integrity of tablet were investigated. Addition of Citric acid caused the enhancement in drug release and disintegration of tablet that was retarded by incorporation of stearic acid in the formulation. Addition of high level of HPMC K100M didn’t significantly retard the burst effect and tablet disintegration produced by citric acid but addition of stearic acid was necessary to retard the same. Formulations were evaluated for in vitro drug release profile, swelling characteristics. The similarity factor, dissolution kinetics, and t50 were used as parameters for selection of the best batch. The in vitro drug release followed Korsemeyer-Peppas kinetics and the drug release mechanism was found to be of anomalous type. For the developed formulation, the value of n was found to be 0.6039 while for the marketed formulation the value was 0.5889 indicating the anomalous transport. The similarity factor f2 was found to be 78.19 for the developed formulation indicating the release was almost similar to that of the marketed formulation (Asthalin SA8).
Key words: Floating, Salbutamol sulphate, Hydroxypropyl methylcellulose, anomalous transport.
The present investigation concerns the development of the floating matrix tablets of Salbutamol Sulphate. Tablets were prepared by wet granulation method and were characterized using the official method. Hydroxypropyl methylcellulose was used as a release retardant material. Sodium bicarbonate and Citric acid was incorporated as a gas-generating agent. The effects of citric acid on drug release profile, floating properties and matrix integrity of tablet were investigated. Addition of Citric acid caused the enhancement in drug release and disintegration of tablet that was retarded by incorporation of stearic acid in the formulation. Addition of high level of HPMC K100M didn’t significantly retard the burst effect and tablet disintegration produced by citric acid but addition of stearic acid was necessary to retard the same. Formulations were evaluated for in vitro drug release profile, swelling characteristics. The similarity factor, dissolution kinetics, and t50 were used as parameters for selection of the best batch. The in vitro drug release followed Korsemeyer-Peppas kinetics and the drug release mechanism was found to be of anomalous type. For the developed formulation, the value of n was found to be 0.6039 while for the marketed formulation the value was 0.5889 indicating the anomalous transport. The similarity factor f2 was found to be 78.19 for the developed formulation indicating the release was almost similar to that of the marketed formulation (Asthalin SA8).
Key words: Floating, Salbutamol sulphate, Hydroxypropyl methylcellulose, anomalous transport.
July - 2010 / Volume - 2/Issue - 5
( Total Articles =15 )
( Total Articles =15 )
July 2010 Issue
Article No 15
July - 2010 / Volume - 2 / Issue - 5/ Article No - 10 / Research Article
DEVELOPMENT AND EVALUATION OF FLOATING TABLETS OF SALBUTAMOL SULPHATE.
Sharad N. Shinde*, Satej S. Magdum,
Shekhar B. Waikar,
Maesh R. Mishra, Kamla K. Chandak
S.K.B. College of Pharmacy, Nagpur,
Maharashtra, India.
Email:sharad_shinde10@yahoo.com
July - 2010 / Volume - 2 / Issue - 5/ Article No - 10 / Research Article
DEVELOPMENT AND EVALUATION OF FLOATING TABLETS OF SALBUTAMOL SULPHATE.
Sharad N. Shinde*, Satej S. Magdum,
Shekhar B. Waikar,
Maesh R. Mishra, Kamla K. Chandak
S.K.B. College of Pharmacy, Nagpur,
Maharashtra, India.
Email:sharad_shinde10@yahoo.com
Sharad Shinde
