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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

   In the present work one spectrophotometric and one visible spectrophotometric method have been developed for determination of rupatadine fumarate in bulk and tablet formulations. The first developed method is based on the preparation of calibration curve between absorbance at maximum wavelength ( 268.44 nm) and concentration of rupatadine fumarate against a reagent blank of 0.1 N HCl. Beer’s law in the concentration range of 10-50 µg/ml of rupatadine fumarate. The second developed method is based on formation of chloroform extractable complex of drug with bromocresol green. The absorbance maximum of chloroform layer was measured at 422.42 nm. Percentage label claim of tablet formulation using both the  method was found to be in the range of 99.11 % - 99.56 %. Recovery studies were carried out for the developed methods and the results were found to be satisfactory. The developed methods can be used with any model of spectrophotometer and does not require sophisticated recording spectrophotometer. Results of analysis for both the methods were validated statistically that indicates a high level of precision as evidenced by low standard deviation (SD) values. Therefore the methods were found to be simple, sensitive, accurate economic and reproducible.



        

Key words:
Rupatadine Fumarate; UV and visible spectrophotometry; quantitative estimation; bromocresol green
June - 2010 / Volume - 2/Issue - 4
( Total Articles =15 )
June 2010 Issue
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Article No 14
June - 2010 / Volume - 2 / Issue - 4/ Article No - 10 / Research Article

DEVELOPMENT OF UV AND VISIBLE SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF RUPATADINE FUMARATE FROM TABLET FORMULATION


Goyal Anju1*,
C. S. Sharma1 ,Singh Gurvinder1


1 B. N. Girl’ s College of Pharmacy,
Udaipur-313003, India
Email:goyalanjugoyal@yahoo.co.in
Dr. Anju Goyal