Copyright © 2009 by "International Journal of Pharmaceutica Research and Development" · All Rights reserved · E-Mail: info@ijprd.com
HOW TO PREPARE
YOUR PAPER
YOUR PAPER
Past Issues
March 2009
April 2009
May 2009
June 2009
July 2009
August 2009
September 2009
October 2009
November 2009
December 2009
January 2010
February 2010
March 2010
April 2010
May 2010
March 2009
April 2009
May 2009
June 2009
July 2009
August 2009
September 2009
October 2009
November 2009
December 2009
January 2010
February 2010
March 2010
April 2010
May 2010
Online Since : March 2009
Only 15 Articles will be Published in Each Issues
TODAY IS
INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
ABSTRACT
Etoricoxib, a non-steroidal anti-inflammatory drug, is used to Osteoarthritis, Rheumatoid arthritis and Acute Gouty arthritis. Etoricoxib is practically insoluble in water , hence present study was carried out to enhance dissolution properties of Etoricoxib. Through the preparation of Solid Dispersions using PVPK-30, as carrier at various proportions (1:1,1:3,1:6, 1:9) by using different techniques like Physical mixtures, Kneading Method and Solvent Evaporation Method. The drug release profile was studied in 900ml.0.1N HCl containing 0.75% SLS. U.V. Spectrophotometric method was selected for assay as well as in-vitro dissolution studies at 234nm. The dispersions were evaluated for drug content uniformity dissolution rate study, DE20, T50, Reproducibility and ANOVA. The FTIR and DSC were used to characterize the solid state of solid dispersions. A marked increase in dissolution rate was observed with all solid dispersions; among that Etoricoxib with PVP K-30 (1:6) Solvent evaporation method gave highest dissolution. The increase in dissolution rate of the drug may be due to increased wettability, hydrophilic nature of the carrier and also possibility due to reduction in drug crystalinity.
Key words: Solid dispersion, Etoricoxib, Physical mixtures, Kneading method, Solvent evaporation method, Polyvinyl pyrrolidone.
Etoricoxib, a non-steroidal anti-inflammatory drug, is used to Osteoarthritis, Rheumatoid arthritis and Acute Gouty arthritis. Etoricoxib is practically insoluble in water , hence present study was carried out to enhance dissolution properties of Etoricoxib. Through the preparation of Solid Dispersions using PVPK-30, as carrier at various proportions (1:1,1:3,1:6, 1:9) by using different techniques like Physical mixtures, Kneading Method and Solvent Evaporation Method. The drug release profile was studied in 900ml.0.1N HCl containing 0.75% SLS. U.V. Spectrophotometric method was selected for assay as well as in-vitro dissolution studies at 234nm. The dispersions were evaluated for drug content uniformity dissolution rate study, DE20, T50, Reproducibility and ANOVA. The FTIR and DSC were used to characterize the solid state of solid dispersions. A marked increase in dissolution rate was observed with all solid dispersions; among that Etoricoxib with PVP K-30 (1:6) Solvent evaporation method gave highest dissolution. The increase in dissolution rate of the drug may be due to increased wettability, hydrophilic nature of the carrier and also possibility due to reduction in drug crystalinity.
Key words: Solid dispersion, Etoricoxib, Physical mixtures, Kneading method, Solvent evaporation method, Polyvinyl pyrrolidone.
June - 2010 / Volume - 2/Issue - 4
( Total Articles =15 )
( Total Articles =15 )
June 2010 Issue
Article No 9
June - 2010 / Volume - 2 / Issue - 4 / Article No - 9 /Research Article
STUDIES TO ENHANCE DISSOLUTION PROPERTIES OF ETORICOXIB
S. Muralidhar1*, G. Devala Rao2,
R. Ramesh1. T.V.Narayana1.
1Dr HLT. College of pharmacy,
Kengal Channpatana 571502.India
2K.V.S.R Siddhartha College of
Pharmaceutical Sciences , Vijayawada, India
E-Mail : suripeddi2007@yahoo.com
June - 2010 / Volume - 2 / Issue - 4 / Article No - 9 /Research Article
STUDIES TO ENHANCE DISSOLUTION PROPERTIES OF ETORICOXIB
S. Muralidhar1*, G. Devala Rao2,
R. Ramesh1. T.V.Narayana1.
1Dr HLT. College of pharmacy,
Kengal Channpatana 571502.India
2K.V.S.R Siddhartha College of
Pharmaceutical Sciences , Vijayawada, India
E-Mail : suripeddi2007@yahoo.com
S. Muralidhar
