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Online Since : March 2009
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
ABSTRACT
Present study was designed to evaluate Glimepiride on cardiovascular complication in normal and Streptozotocin-Nicotinamide induced diabetic in rats. Glimepiride (0.5 mg/kg, p.o) was administered for 28 days in rats injected with single dose of Streptozotocin (65 mg/kg, i.p, STZ) and Nicotinamide (10.5 mg/kg, i.p, NIC) and after isoproterenol (200mg/kg, s.c., ISO) induced myocardial infarction in rats on 29th and 30th day. At the end of experimental period (i.e. on the day 31) blood samples were collected and animals were euthanized. A heart tissue sample of each rat was collected and glycogen and nitrite carried out for further estimations. Administration of STZ-NIC in rats showed a significant (p<0.001) increased in the levels of serum glucose, glycosylated heamoglobin (HbA1c), creatine kinase (CK), Glutamate oxaloacetate transferase (GOT), glycogen and nitrite whereas the levels of myocardial infarct size was found low to be significant (p<0.05). ). Treatment with Glimepiride significantly (P<0.001) decreased HbA1c, glucose level and significantly (P<0.05) reduced glycogen and nitrite in compared to diabetic control group. The myocardial infarction in diabetic rats also led to severe splaying of muscle fiber, heavy neutrophil infiltration and cellular edema than non diabetic rats. The GLI treated diabetic rats exhibited reduction in necrosis with less fragmentation of fibres as compared to diabetic control groups, which reflects the cardio protective effect of GLI. This study concluded that GLI at 0.5 mg/kg may show reduce experimentally induced myocardial infarction in type 2 diabetic rats.
Key words: Glimepiride, cardioprotective, isoproterenol, Type 2 diabetic, Histopathology
Present study was designed to evaluate Glimepiride on cardiovascular complication in normal and Streptozotocin-Nicotinamide induced diabetic in rats. Glimepiride (0.5 mg/kg, p.o) was administered for 28 days in rats injected with single dose of Streptozotocin (65 mg/kg, i.p, STZ) and Nicotinamide (10.5 mg/kg, i.p, NIC) and after isoproterenol (200mg/kg, s.c., ISO) induced myocardial infarction in rats on 29th and 30th day. At the end of experimental period (i.e. on the day 31) blood samples were collected and animals were euthanized. A heart tissue sample of each rat was collected and glycogen and nitrite carried out for further estimations. Administration of STZ-NIC in rats showed a significant (p<0.001) increased in the levels of serum glucose, glycosylated heamoglobin (HbA1c), creatine kinase (CK), Glutamate oxaloacetate transferase (GOT), glycogen and nitrite whereas the levels of myocardial infarct size was found low to be significant (p<0.05). ). Treatment with Glimepiride significantly (P<0.001) decreased HbA1c, glucose level and significantly (P<0.05) reduced glycogen and nitrite in compared to diabetic control group. The myocardial infarction in diabetic rats also led to severe splaying of muscle fiber, heavy neutrophil infiltration and cellular edema than non diabetic rats. The GLI treated diabetic rats exhibited reduction in necrosis with less fragmentation of fibres as compared to diabetic control groups, which reflects the cardio protective effect of GLI. This study concluded that GLI at 0.5 mg/kg may show reduce experimentally induced myocardial infarction in type 2 diabetic rats.
Key words: Glimepiride, cardioprotective, isoproterenol, Type 2 diabetic, Histopathology
April - 2010 / Volume - 2/Issue - 3
( Total Articles =15 )
( Total Articles =15 )
May 2010 Issue
Article No 15
May - 2010 / Volume - 2 / Issue - 3/ Article No - 10 / Research Article
EFFECT OF GLIMEPIRIDE ON CARDIOVASCULAR COMPLICATION IN DIABETES – AN EXPERIMENTALLY STUDY IN RATS
Jagdish Kakadiya*, Nehal Shah, Jagrut Shroff
Dharmaj Degree Pharmacy College,
Petlad-Khambhat Road,
Dharmaj, Anand-388430, Gujarat, INDIA
Email:jagdishkakadiya@yahoo.co.in
May - 2010 / Volume - 2 / Issue - 3/ Article No - 10 / Research Article
EFFECT OF GLIMEPIRIDE ON CARDIOVASCULAR COMPLICATION IN DIABETES – AN EXPERIMENTALLY STUDY IN RATS
Jagdish Kakadiya*, Nehal Shah, Jagrut Shroff
Dharmaj Degree Pharmacy College,
Petlad-Khambhat Road,
Dharmaj, Anand-388430, Gujarat, INDIA
Email:jagdishkakadiya@yahoo.co.in
Jagdish K.
June 2010 Issue